| AMG S 65 V12 • 630 HP • G-TRONIC | 630 HP | 4.3 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| AMG S 63 V8 • 612 HP • 4MATIC G-TRONIC | 612 HP | 3.5 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 600 V12 • 530 HP • G-TRONIC | 530 HP | 4.6 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 560e V6 • 476 HP • Plug-in Hybrid 9G-TRONIC | 476 HP | 5 sec | 250 km/h | 9-speed automatic | Petrol / electricity |
| S 560 V8 • 469 HP • 4MATIC G-TRONIC | 469 HP | 4.6 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 560 V8 • 469 HP • G-TRONIC | 469 HP | 4.7 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 500 • 435 HP • EQ Boost G-TRONIC | 435 HP | 4.8 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 450 • 367 HP • EQ Boost 4MATIC G-TRONIC | 367 HP | 4.9 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 450 • 367 HP • EQ Boost G-TRONIC | 367 HP | 5.1 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 400d • 340 HP • G-TRONIC | 340 HP | 5.4 sec | 250 km/h | 9-speed automatic | Diesel |
| S 400d • 340 HP • 4MATIC G-TRONIC | 340 HP | 5.2 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d • 286 HP • G-TRONIC | 286 HP | 6 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d • 286 HP • 4MATIC G-TRONIC | 286 HP | 5.8 sec | 250 km/h | 9-speed automatic | Diesel |
