| S 600 V12 • 394 HP • 5G-TRONIC | 394 HP | 6.6 sec | 250 km/h | 5-speed automatic | Petrol (Gasoline) |
| S 600 V12 • 394 HP • 4G-TRONIC | 394 HP | 6.6 sec | 250 km/h | 4-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 320 HP • 5G-TRONIC | 320 HP | 7.3 sec | 250 km/h | 5-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 320 HP • 4G-TRONIC | 320 HP | 7.3 sec | 250 km/h | 4-speed automatic | Petrol (Gasoline) |
| S 420 V8 • 279 HP • 5G-TRONIC | 279 HP | 8.3 sec | 245 km/h | 5-speed automatic | Petrol (Gasoline) |
| S 420 V8 • 279 HP • 4G-TRONIC | 279 HP | 8.3 sec | 245 km/h | 4-speed automatic | Petrol (Gasoline) |
| S 320 • 231 HP • 4G-TRONIC | 231 HP | 8.9 sec | 225 km/h | 4-speed automatic | Petrol (Gasoline) |
| S 320 • 231 HP • 5G-TRONIC | 231 HP | 8.9 sec | 225 km/h | 5-speed automatic | Petrol (Gasoline) |
| S 280 • 193 HP • 5G-TRONIC | 193 HP | 11 sec | 210 km/h | 5-speed automatic | Petrol (Gasoline) |
| S 280 • 193 HP | 193 HP | 11 sec | 215 km/h | 5-speed manual | Petrol (Gasoline) |
| S 280 • 193 HP • 4G-TRONIC | 193 HP | 11 sec | 210 km/h | 4-speed automatic | Petrol (Gasoline) |
| S 300 Turbodiesel • 177 HP • 5G-TRONIC | 177 HP | 11.2 sec | 206 km/h | 5-speed automatic | Diesel |
| S 350 Turbodiesel • 150 HP • 4G-TRONIC | 150 HP | 13.1 sec | 185 km/h | 4-speed automatic | Diesel |