| AMG S 63 • 585 HP • SPEEDSHIFT | 585 HP | - | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 500 • 455 HP • 4MATIC 7G-TRONIC | 455 HP | 4.8 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 500 • 455 HP • 7G-TRONIC | 455 HP | 4.8 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 455 HP • 4MATIC 9G-TRONIC | 455 HP | 4.8 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 500 V8 • 455 HP • 9G-TRONIC | 455 HP | 4.8 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 400 V6 • 333 HP • 4MATIC 7G-TRONIC PLUS | 333 HP | 6.1 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 400 • 333 HP • HYBRID 7G-TRONIC | 333 HP | 6.8 sec | 250 km/h | 7-speed automatic | Petrol (Gasoline) |
| S 350d • 258 HP • 9G-TRONIC | 258 HP | 6.5 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350 BlueTEC • 258 HP • 4MATIC 7G-TRONIC | 258 HP | 6.8 sec | 250 km/h | 7-speed automatic | Diesel |
| S 350d • 258 HP • 4MATIC 9G-TRONIC | 258 HP | 6.5 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350 BlueTEC • 258 HP • 7G-TRONIC | 258 HP | 6.8 sec | 250 km/h | 7-speed automatic | Diesel |
| S 300 BlueTEC • 231 HP • HYBRID 7G-TRONIC | 231 HP | 7.6 sec | 240 km/h | 7-speed automatic | Diesel |