| S 580e • 510 HP • Plug-in Hybrid 9G-TRONIC | 510 HP | 5.2 sec | 250 km/h | 9-speed automatic | Petrol / electricity |
| S 580e • 510 HP • Plug-in Hybrid 4MATIC 9G-TRONIC | 510 HP | 4.9 sec | 250 km/h | 9-speed automatic | Petrol / electricity |
| S 580 V8 • 503 HP • EQ Boost 4MATIC 9G-TRONIC | 503 HP | 4.4 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 500 • 449 HP • EQ Boost 4MATIC 9G-TRONIC | 449 HP | 4.7 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 500 • 435 HP • EQ Boost 4MATIC 9G-TRONIC | 435 HP | 4.9 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 450e • 408 HP • Plug-in Hybrid 9G-TRONIC | 408 HP | 5.9 sec | 250 km/h | 9-speed automatic | Petrol / electricity |
| S 450 • 381 HP • EQ Boost 4MATIC 9G-TRONIC | 381 HP | 5 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 450d • 367 HP • EQ Boost 4MATIC 9G-TRONIC | 367 HP | 5 sec | 250 km/h | 9-speed automatic | Diesel |
| S 450 • 367 HP • EQ Boost 4MATIC 9G-TRONIC | 367 HP | 5.1 sec | 250 km/h | 9-speed automatic | Petrol (Gasoline) |
| S 400d • 330 HP • 4MATIC 9G-TRONIC | 330 HP | 5.4 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d • 313 HP • EQ Boost 4MATIC 9G-TRONIC | 313 HP | 5.5 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d • 313 HP • EQ Boost 9G-TRONIC | 313 HP | 5.6 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d • 286 HP • 9G-TRONIC | 286 HP | 6.4 sec | 250 km/h | 9-speed automatic | Diesel |
| S 350d • 286 HP • 4MATIC 9G-TRONIC | 286 HP | 6.2 sec | 250 km/h | 9-speed automatic | Diesel |
